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Trans-resveratrol - guardian of youth

Trans-resveratrol - guardian of youth

In the realm of natural health supplements, few compounds have garnered as much attention and intrigue as resveratrol, affectionately known as RV. This polyphenol, found in various plant sources including red grapes and berries, has been heralded for its potential to combat a wide array of chronic diseases. Let's delve into the fascinating world of trans-resveratrol and uncover its comprehensive defence against chronic ailments.

Neurological Diseases and Cognitive Performance

Resveratrol emerges as a promising ally in the battle against neurological diseases, particularly Alzheimer's. Studies administering around 500 mg of RV daily to Alzheimer's patients have shown encouraging results, including reduced levels of beta-amyloid in the brain, a key hallmark of the disease [1]. Additionally, RV exhibits potential in enhancing cognitive function, offering hope for those grappling with cognitive decline [2].

Diabetes

For individuals grappling with diabetes, resveratrol holds significant promise. By enhancing insulin sensitivity and reducing postprandial glucose spikes, RV may help individuals better manage their blood sugar levels [3]. However, its interactions with diabetes medications necessitate further exploration to optimize its therapeutic benefits.

Cancer

Resveratrol's anti-cancer properties are nothing short of remarkable. By modulating the insulin-like growth factor (IGF) signaling pathway, RV acts as a potent chemopreventive agent, reducing the risk of cancer development. Optimal doses of RV have been shown to significantly decrease IGF levels, underscoring its potential as a formidable weapon in the fight against cancer [4].

Obesity

In the battle against obesity, resveratrol emerges as a metabolic superhero. By mimicking the effects of calorie restriction [5], RV promotes fat metabolism, enhances energy production, and improves insulin sensitivity, offering hope for effective weight management strategies.

Cardiovascular Diseases

Resveratrol's cardiovascular benefits are equally impressive. Studies have demonstrated its ability to enhance vascular function, improve blood vessel flexibility [6], and offer protection against various cardiovascular conditions. However, its effects on heart health may vary depending on factors such as dosage and individual characteristics.

Other Benefits

Resveratrol's therapeutic reach extends beyond the realms of diabetes, cancer, and cardiovascular health. It shows promise in mitigating metabolic syndrome [7], inflammatory diseases [8], kidney diseases [9], and other conditions associated with oxidative stress and inflammation.

Key Component(s):

Resveratrol (trans‐3,5,4′‐trihydroxystilbene)

Recommended Usage

For optimal benefits, consume 500 mg of resveratrol every morning.

Clinical Trials

The wealth of clinical studies conducted on resveratrol underscores its potential as a therapeutic agent across various health conditions. With 209 clinical trials as of December 2023, resveratrol continues to captivate researchers and health enthusiasts alike.

Caution

While resveratrol has been deemed safe at doses up to 5 g/day, higher doses may result in adverse effects such as nausea and gastrointestinal discomfort. Understanding resveratrol's bioavailability and pharmacokinetics is crucial for optimizing its therapeutic efficacy and minimizing potential side effects.

Harness the Power of Resveratrol

Unlock the potential of resveratrol and embark on a journey toward comprehensive health and vitality. Embrace nature's gift and harness the power of resveratrol to safeguard your well-being against the ravages of chronic diseases.

 

[1] Turner, R. S., Thomas, R. G., Craft, S., Van Dyck, C. H., Mintzer, J., Reynolds, B. A., Brewer, J. B., Rissman, R. A., Raman, R., Aisen, P. S., For the Alzheimer’s Disease Cooperative Study, Alzheimer’s Disease Cooperative Study, Mintzer, J., Reynolds, B. A., Karlawish, J., Galasko, D., Heidebrink, J., Aggarwal, N., Graff-Radford, N., … Alexopoulis, G. (2015). A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology, 85(16), 1383–1391. https://doi.org/10.1212/WNL.0000000000002035

[2] Wong, R., Raederstorff, D., & Howe, P. (2016). Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus. Nutrients, 8(7), 425. https://doi.org/10.3390/nu8070425
[3] Brasnyó, P., Molnár, G. A., Mohás, M., Markó, L., Laczy, B., Cseh, J., Mikolás, E., Szijártó, I. A., Mérei, Á., Halmai, R., Mészáros, L. G., Sümegi, B., & Wittmann, I. (2011). Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. British Journal of Nutrition, 106(3), 383–389. https://doi.org/10.1017/S0007114511000316
[4] Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., & Brenner, D. E. (2010). Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis. Cancer Research, 70(22), 9003–9011. https://doi.org/10.1158/0008-5472.CAN-10-2364
[5] Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., Moonen-Kornips, E., Hesselink, M. K. C., Kunz, I., Schrauwen-Hinderling, V. B., Blaak, E. E., Auwerx, J., & Schrauwen, P. (2011). Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans. Cell Metabolism, 14(5), 612–622. https://doi.org/10.1016/j.cmet.2011.10.002
[6] Wong, R. H. X., Howe, P. R. C., Buckley, J. D., Coates, A. M., Kunz, I., & Berry, N. M. (2011). Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutrition, Metabolism and Cardiovascular Diseases, 21(11), 851–856. https://doi.org/10.1016/j.numecd.2010.03.003
[7] Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Geny, B., Laakso, M., Puigserver, P., & Auwerx, J. (2006). Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α. Cell, 127(6), 1109–1122. https://doi.org/10.1016/j.cell.2006.11.013
[8] Espinoza, J. L., Trung, L. Q., Inaoka, P. T., Yamada, K., An, D. T., Mizuno, S., Nakao, S., & Takami, A. (2017). The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans. Oxidative Medicine and Cellular Longevity, 2017, 1–10. https://doi.org/10.1155/2017/6781872
[9] Chen, S., Li, B., Chen, L., & Jiang, H. (2023). Uncovering the mechanism of resveratrol in the treatment of diabetic kidney disease based on network pharmacology, molecular docking, and experimental validation. Journal of Translational Medicine, 21(1), 380. https://doi.org/10.1186/s12967-023-04233-0
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